Cytoflavin in the Rehabilitation of Post-intensive Care Syndrome in Stroke Survivors

Inclusion Criteria: * Men and women aged 18 years and above; * Patients who underwent ischemic stroke; * The period from the development of ischemic stroke is not less than 12 and not more than 28 days; * Staying in intensive care unit for no less than 72 hours; * Diagnosed post-intensive care syndrome (PICS); * Functional status assessed using the modified Rankin scale amounts to 4-5; * Gravity gradient of 20° to 40° upon inclusion in observational non-interventional program Exclusion Criteria: * Vegetative state; * Mechanical ventilation lasting more than 72 hours after the development of ischemic stroke; * Surgical treatment for cerebral stroke (decompressive craniectomy; thromboextraction etc.); * Premorbid (before the development of ischemic stroke) level of functional activity assessed using the modified Rankin scale amounts to 4 or 5; * Signs of increasing neurological deficit or enlargement of hypoperfusion zones on CT scans within 24 hours before inclusion in observational non-interventional program; * Level of consciousness ≤ 5 according to Glasgow Coma Scale and/or ≥ 1 according to Richmond Agitation-Sedation Scale (RASS); * Behavioral Pain Scale (BPS) or Visual Analogue Scale assessment score of more than \> 0 at the moment of inclusion; * Systolic blood pressure \< 90 and \> 180 mm Hg; * Diastolic blood pressure ≥ 110 mm Hg; * Mean ABP \< 60 mm Hg; * Clinical and/or electrocardiographic signs of acute coronary syndrome (including de novo ST elevation or depres…