A Clinical Trial to Evaluate the Safety and Immunogenicity of Norovirus Bivalent Vaccine

Inclusion Criteria: * Aged 6 months to 59 years old, can provide legal identification of Chinese population; * Based on medical history and physical examination, determined by the researcher as healthy; * Volunteer legal guardians or trustees have the ability to understand (non-illiterate) research procedures, sign informed consent voluntarily with informed consent, and be able to comply with the requirements of clinical research protocols; * Female subjects of childbearing age were not pregnant at the time of enrollment (negative urine pregnancy test), were not breastfeeding, and had no birth plan within the first 3 months after enrollment; effective contraceptive measures were taken within 2 weeks before enrollment. Exclusion Criteria: * Axillary body temperature before inoculation on the day of entry\> 37.0 ℃; * Congenital malformations or developmental disorders, genetic defects, severe malnutrition, etc .; * Have a history of epilepsy, convulsions or convulsions, or a family history of mental illness; * Those who received immunoenhancement or inhibitor therapy within months (continuous oral or instillation for more than 14 days); * Have been diagnosed with congenital or acquired immunodeficiency, HIV infection, lymphoma, leukemia or other autoimmune diseases; * No spleen or spleen function defect caused by any situation; * Severe liver and kidney disease, drug-uncontrollable hypertension (systolic blood pressure\> 140mmHg, diastolic blood pressure\> 90mmHg), diabetic …