The objective of this research is to measure certain indicators of resiliency to better understand which participants who are over 60 years old will respond more positively to bone marrow transplant. This research is being done to determine if there are traits that make recipients more likely to bounce back following allogeneic bone marrow transplant (BMT).
Age range
60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Change in Physical Performance as assessed by Short Physical Performance Battery (SPPB)
Timeframe: Pre-BMT, Day 30 and Day 180 post transplant
Change in ability to perform activities of daily living as assessed by Instrumental Activities of Daily Living questionnaire
Timeframe: Pre-BMT, Day 30 and Day 180 post transplant
Change in upper extremity function as assessed by accelerometry
Timeframe: 7 consecutive days pre-BMT, at Day 30 and at Day 180
Change in catecholamines levels as assessed in overnight urine collection samples
Timeframe: Pre-BMT, Day 30 and Day 180 post transplant
Change in Frailty as assessed by the Frailty Phenotype instrument
Timeframe: Pre-BMT, Day 30 and Day 180 post transplant
Change in Pittsburgh Fatigability Scale for Older Adults score
Timeframe: Pre-BMT, Day 30 and Day 180 post transplant
Change in Borg Rating of Perceived Exertion Scale score
Timeframe: Pre-BMT, Day 30 and Day 180 post transplant
Change in medical history and diseases/conditions self reporting
Timeframe: Pre-BMT and Day 180 post transplant
Change in health behaviors as assessed by a questionnaire
Timeframe: Pre-BMT and Day 180 post transplant
Change in reporting of patients traumas as assessed by the Hospitalizations, Surgeries, and Falls Questionnaire
Timeframe: Pre-BMT and Day 180 post transplant
Change in pain reporting as assessed by the Pain Assessment Questionnaire
Timeframe: Pre-BMT and Day 180 post transplant
Change in anxiety reporting as assessed by the anxiety questionnaire
Timeframe: Pre-BMT and Day 180 post transplant
Change in trauma reporting as assessed by the trauma questionnaire
Timeframe: Pre-BMT and Day 180 post transplant
Change in cognitive function as assessed by Modified Mini-Mental State Examination
Timeframe: Pre-BMT, Day 30, Day 56 and Day 180 post transplant
Change in cognitive ability as assessed by the Montreal Cognitive Assessment
Timeframe: Pre-BMT, Day 30, Day 56 and Day 180 post transplant
Change in cognitive function as assessed by the Digit Symbol Substitution Test (DSST)
Timeframe: Pre-BMT, Day 30, Day 56 and Day 180 post transplant
Change in ability to cope with life challenges as assessed by the Coping Self-Efficacy Scale
Timeframe: Pre-BMT and Day 180 post transplant
Change in sense of well-being as assessed by the Subscale of Ryff Psychological Well-being Scale
Timeframe: Pre-BMT and Day 180 post transplant
Change in perception and satisfaction with life as assessed by the Meaning in Life Questionnaire and Scale
Timeframe: Pre-BMT and Day 180 post transplant
Change in personality as measured by the Ten Item Personality Inventory (TIPI) Scale
Timeframe: Pre-BMT and Day 180 post transplant
Change in optimism as assessed by the Life Orientation Scale-Revised
Timeframe: Pre-BMT and Day 180 post transplant
Change in perceived loneliness as assessed by the Loneliness Scale
Timeframe: Pre-BMT and Day 180 post transplant
Change in perceived socio-economic status as assessed by the US socioeconomic questionnaire
Timeframe: Pre-BMT and Day 180 post transplant
Change in perceived financial strain as assessed by Financial Strain questionnaire
Timeframe: Pre-BMT and Day 180 post transplant
Change in feeling of community inclusion as assessed by the Social Cohesion Questionnaire
Timeframe: Pre-BMT and Day 180 post transplant
Change in feeling of isolation as assessed by the Social Isolation/Engagement Questionnaire
Timeframe: Pre-BMT and Day 180 post transplant
Change in perceived confidence in spirituality as assessed by the Religion/Spirituality Questionnaire
Timeframe: Pre-BMT and Day 180 post transplant
Change in feelings of depression as assessed by the Patient Health Questionnaire
Timeframe: Pre-BMT and Day 180 post transplant
Change in perceived childhood trauma as assessed by the Adverse Childhood Events (ACE) Scale
Timeframe: Pre-BMT and Day 180 post transplant
Changes in perceived stress as assessed by the Perceived Stress Scale
Timeframe: Pre-BMT and Day 180 post transplant
Change in bone marrow cell ratios as assessed by Bone Marrow Aspirate
Timeframe: pre-transplant and at Day 180 post-transplant
Change in hemoglobin tests.
Timeframe: pre-transplant and then at Day 30, Day 56 and Day 180 post-transplant
changes in salivary plasma free cortisol collection
Timeframe: single 24 hour period before BMT and at Day 180 post-transplant
Change in cortisol level
Timeframe: pre-transplant and at Day 180 post-transplant
Changes in interleukin (IL)-6 level
Timeframe: pre-transplant and at Day 180 post-transplant
Change in dehydroepiandrosterone (DHEA) level
Timeframe: pre-transplant and at Day 180 post-transplant
Change in glucose tolerance as assessed by the Oral Glucose Tolerance Test (OGTT)
Timeframe: pre-transplant and at Day 180 post-transplant
Change in heart rate variability as assessed by the "myPatch" Holter monitor
Timeframe: During clinic visits at pre-transplant, Day 30, Day 56 and Day 180
Change in attention as assessed by the Flanker Inhibitory Control and Attention Test score
Timeframe: pre-transplant, once a week from Day of transplant to Day 60 and at Day 180 post-transplant