A Study to Evaluate the Effect of AZD8154 Administered Via Nebulizer Once Daily in Subjects With Mild Allergic Asthma Challenged With an Inhaled Allergen

Exclusion criteria

• ✕. lung disease (excluding sleep apnea) other than mild allergic asthma
• ✕. history of diabetes, metabolic syndrome, Gilbert syndrome, hepatic impairment, hypertriglyceridemia, or familial lipid disorders
• ✕. clinically significant hypotensive episodes or symptoms of fainting, dizziness, or light headedness
• ✕. cardiovascular disease, particularly coronary artery disease, hypertension, congestive heart failure or any clinically important abnormalities in rhythm, conduction or morphology of the ECG at rest that may interfere with the interpretation of QT interval corrected (QTc) interval changes.
• ✕. significant neurologic disease, including transient ischemic attack, stroke, or seizure disorder
• ✕. alcoholism, drug dependency or abuse
• ✕. latent or chronic infection (eg, recurrent sinusitis, genital or ocular herpes, urinary tract infection) or at risk of infection (eg, surgery) within 90 days of screening
• ✕. malignancy in the previous 5 years other than superficial basal cell carcinoma.