A Study to Test the Effect of Empagliflozin in Patients Who Are in Hospital for Acute Heart Failure

Inclusion Criteria: * Currently hospitalised for the primary diagnosis of acute heart failure (de novo or decompensated chronic HF), regardless of ejection fraction (EF). Patients with a diagnosis of hospitalized heart failure must have HF symptoms at the time of hospital admission * Evidence of left ventricular ejection fraction (LVEF, either reduced or preserved EF) as per local reading preferably measured during current hospitalisation or in the 12 months prior to randomisation * Patients must be randomised after at least 24 hours and no later than 5 days after admission, as early as possible after stabilization and while still in hospital * Patients must fulfil the following stabilisation criteria (while in the hospital): * SBP ≥100mm Hg and no symptoms of hypotension in the preceding 6 hours, * no increase in i.v. diuretic dose for 6 hours prior to randomisation, * no i.v. vasodilators including nitrates within the last 6 hours prior to randomisation * no i.v. inotropic drugs for 24 hours prior to randomisation. * Elevated NT-proBNP ≥ 1600pg/mL or BNP ≥400 pg/mL according to the local lab, for patients without atrial fibrillation (AF); or elevated NT-proBNP ≥ 2400pg/mL or BNP ≥600 pg/mL for patients with AF, measured during the current hospitalization or in the 72 hours prior to hospital admission,. For patients treated with an angiotensin receptor neprilysin inhibitor (ARNI) in the previous 4 weeks prior to randomisation, only NT-proBNP values should be used *…