Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab. (NCT04157348) | Clinical Trial Compass
Active — Not RecruitingPhase 3
Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab.
United States140 participantsStarted 2019-10-29
Plain-language summary
This is a randomized, double blind, active-controlled, parallel group, multicenter 52-week Phase 3 study to compare the efficacy and safety of benralizumab 30 mg versus mepolizumab 300 mg administered by subcutaneous (SC) injection in patients with relapsing or refractory EGPA on corticosteroid therapy with or without stable immunosuppressive therapy.
All patients who complete the 52-week double-blind treatment period on IP may be eligible to continue into an open label extension (OLE) period. The OLE period is intended to allow each patient at least 1 year of treatment with open-label benralizumab 30 mg administered SC (earlier enrolled patients may therefore be in the OLE for longer than 1 year).
Who can participate
Age range18 Years – 130 Years
SexALL
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Inclusion criteria
✓. Male or female subjects age 18 years or older.
✓. EGPA diagnosis based on history or presence asthma and eosinophilia (\>1.0x10\^9/L and/or \>10% of leucocytes) and at least 2 of; biopsy with eosinophilic vasculitis or perivascular/granulomatous inflammation; mono-or polyneuropathy, non-fixed pulmonary infiltrates, sino-nasal abnormality; cardiomyopathy; glomerulonephritis; alveolar haemorrhage; palpable purpura; anti neutrophil cytoplasmic anti-body (ANCA) positivity (Myeloperoxidase or proteinease 3).
✓. History of relapsing (at least 1 confirmed EGPA relapse within last 2 years and \> 12 weeks prior to screening), or refractory (failure to attain remission, defined as BVAS=0 and oral corticosteroid (OCS) dose \<=7.5 mg/day of prednisolone or equivalent, following standard induction regimen for at least 3 months and within 6 months prior to screening, or recurrence of symptoms upon OCS tapering at any dose of ≥7.5 mg/day prednisolone or equivalent.
✓. Must be on a stable dose of oral prednisolone or prednisone of ≥7.5 mg/day (but not \>50mg/day) for at least 4 weeks prior to randomization.
✓. If receiving immunosuppressive therapy (excluding cyclophosphamide) the dose must be stable for the 4 weeks prior to randomization and during the study (dose reductions for safety reasons will be permitted).
✓. QTc(F)\<450 msec or QTc(F)\<480 msec for patients with bundle branch block.
What they're measuring
1
Number of Subjects Who Achieved Main Remission at Both Weeks 36 and 48
Timeframe: Week 36 and Week 48
2
Supportive Endpoint: Proportion of Subjects Who Achieved Supportive Remission at Both Weeks 36 and 48
. Females of childbearing potential must use an acceptable method of birth control from randomization for at least 12 weeks after the last study drug administration.
Exclusion criteria
✕. Diagnosed with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA)
✕. Organ or life-threatening EGPA \< 3 months prior to screening
✕. Currently pregnant or breastfeeding, or planning to become pregnant during study participation.
✕. Current malignancy or history of malignancy, unless received curative therapy \>5 years ago, or \>1 year ago for basal cell carcinoma, localized squamous cell carcinoma of the skin or in situ carcinoma of the cervix
✕. An untreated or refractory helminth parasitic infection \< 24 weeks prior to screening
✕. Unstable liver disease
✕. Severe or clinically significant, uncontrolled cardiovascular disease
✕. Other concurrent disease that may put the patient at risk, or may influence the results of the study, or the patients' ability to complete entire duration of the study