CompletedNot Applicable

Pilot Study-Quantitative Analysis of Positional Fatty Acids in Postprandial Chylomicron Triacylglycerol Using 13C NMR Spectroscopy

Malaysia14 participantsStarted 2019-10-18

Plain-language summary

13C NMR spectroscopy has been validated to be a rapid, direct and accurate quantitative method in determination of positional distribution of fatty acids in edible oils and fats, including the palm oil fractions (from soft olein to hard stearin). Nevertheless, there is paucity of literature describing its application in determining the positional fatty acid composition in blood triacylglycerols \& biological samples, despite its widely used application in edible oils and fats. The postprandial feeding intervention is aimed to harvest chylomicron rich in triglycerides (\~97% TAG) for NMR analysis.

Who can participate

Age range25 Years – 40 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Non muslim, aged between 25 - 40 yrs old. * BMI between 20 - 27.5 kg/m2. * Blood pressure with \<130mmHg for systolic pressure and \< 80 mmHg for diastolic pressure. * Blood glucose level in the range of 3.9 to 5.5 mmol/L. * Total cholesterol level \< 6.0 mmol/L. * Triglycerides level \< 2.3 mmol/L. * No use of tobacco and no consumption of alcohol. Exclusion Criteria: * Suffer from chronic disease such as CVD, hypertension, diabetic, metabolic syndrome. * Consuming any medical prescriptions/ supplements. * Having blood clotting problem. * Women who are pregnant or lactating. * Hypertensive condition with systolic pressure \>140mmHg and diastolic pressure \> 90 mmHg.

What they're measuring

Triglycerides profile in chylomicron harvested

Timeframe: Up to hour 5

Trial details

NCT IDNCT04156503

SponsorMalaysia Palm Oil Board

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2019-12-30

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