This is a 2-part study of mavorixafor in participants diagnosed with chronic neutropenia. The main goal of Part 1 (Phase 1b) is to help researchers learn more about how the investigational medicine, mavorixafor, impacts people living with chronic neutropenia (including congenital, idiopathic, and cyclic). In Part 2 (Phase 2), the safety and tolerability of chronic dosing of mavorixafor will be evaluated in a larger participant population and the impact of 6-month chronic dosing of mavorixafor on participant neutropenia.
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Number of Participants With Treatment-Emergent Adverse Events (TEAEs) After a Single Dose of Mavorixafor
Timeframe: Baseline through Day 1 and 7 days follow-up
Number of Participants With Treatment-Emergent Adverse Events (TEAEs) After Multiple Doses of Mavorixafor
Timeframe: Baseline through Month 6 and 30 days follow-up
Change From Baseline in Absolute Neutrophil Count (ANC) to 8 hours Post-dose On Day 1
Timeframe: Baseline, 8 hours Post-dose On Day 1
Change From Baseline in ANC to Month 6
Timeframe: Baseline, Month 6