CD34 Selected Allogeneic HCT w/ Myeloablative Conditioning Plus CD8+ Memory TCell Infusion in MDS, AL and CML

Recipient Inclusion Criteria: * Acute leukemia, in morphologic complete remission, OR myelodysplasia with \< 10% blasts in the marrow, and no circulating blasts that contain auer rods. Patients with chronic myelomonocytic leukemia (CMML) must have a WBC count ≤ 10,000 cells/μL and \< 10% blasts in the marrow. * Planned myeloablative conditioning regimen at Stanford University Medical Center. * Karnofsky or Lansky Performance Score ≥ 70%. * Must have an HLA related donor as follows: onor must be an 8/8 match for HLA A, B and C at intermediate (or higher) resolution, and DRB1 at high resolution using DNA based typing. The donors must be willing to receive G CSF followed by collection of cells by apheresis, and must meet the Program's criteria for donation. * Cardiac function: Ejection fraction at rest ≥ 40%. * Serum creatinine value of \< 1.5 mg/dL, or an estimated creatinine clearance greater than 50 mL/minute (using the Stanford calculator for eGFR available in EPIC) * Diffusing capacity of the lungs for carbon monoxide (DLCO) ≥ 50% (adjusted for Hgb) * Forced vital capacity (FVC) ≥ 50%. * Forced expiratory volume (FEV1) ≥ 50%. * Total bilirubin \< 2 times the upper limit of normal (ULN) (unless the elevated bilirubin is attributed to Gilbert's Syndrome) * Alanine aminotransferase (ALT) \< 2.5 x ULN * Aspartate aminotransferase (AST) \< 2.5 x ULN * Total bilirubin \< 2 times the upper limit of normal (unless elevated bilirubin is attributed to Gilbert's Syndrome) * Signed in…