Probiotic (LGG) for Veterans With PTSD

Inclusion criteria * History of at least one deployment in support of OEF/OIF * Current diagnosis of PTSD per the Clinician Administered PTSD Scale-5 (CAPS-5) * Current diagnosis of Functional Bowel Disorder by ROME IV * CRP level of 1.0 mg/L or above at baseline * Medical clearance to participate by study providers * Age between 18 and 60 * Ability to provide informed consent * Willingness to abstain from probiotic supplements (pills, tablets, oils, foods, etc.) other than the investigational product provided until all study procedures are completed * Willingness to provide blood and stool samples Exclusion criteria * Inability to adequately respond to questions regarding the informed consent procedure * Currently involved in the criminal justice system as a prisoner or ward of the state * Non-English speaking * Current (past month) alcohol or substance abuse or dependence * Lifetime history of bipolar disorder or psychosis or anxiety disorders (excluding PTSD). * Consistent (e.g., 5x/week or greater) probiotic supplementation within the last month, including probiotic food products such as yogurt, as determined by phone screen interview and Probiotic Food Check List * Receiving intravenous, intramuscular, or oral antibiotics within the last month * Presence of central venous catheters (CVCs) * Gastrointestinal (GI) barriers as identified by the 2-week run-in period as determined by the study team * Participation in conflicting interventional research protocol * Vital sig…