Effect of Celecoxib on Postoperative Analgesia and Disease Severity in AERD Patients with CRS (NCT04147013) | Clinical Trial Compass
Active — Not RecruitingPhase 4
Effect of Celecoxib on Postoperative Analgesia and Disease Severity in AERD Patients with CRS
Canada, Saudi Arabia44 participantsStarted 2020-02-18
Plain-language summary
This is a proposed randomized prospective study to evaluate both the anti-inflammatory and analgesic effects of a COX-2 inhibitor, celecoxib, in patients with aspirin-exacerbated respiratory disease and Chronic rhinosinusitis following endoscopic sinus surgery.
The investigators hypothesize that supplementation with celecoxib can potentially improve surgical outcomes and reduce the postoperative usage of opioid analgesics without an increased risk of bleeding or asthma exacerbation
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Post FESS changes in the Lund-Kennedy Endoscopic Score (LKES)
Timeframe: 1 week and 4 weeks post-operatively.
2
Post FESS changes in the Peri-Operative Sinus Endoscopy (POSE) score
Timeframe: 1 week and 4 weeks post-operatively.
3
Post FESS changes in the validated Sino-Nasal Outcome Test 22 (SNOT-22) questionnaire
Timeframe: 1 week and 4 weeks post-operatively.
Trial details
NCT IDNCT04147013
SponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's