A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo Aspiration System

Inclusion Criteria: * Patient age ≥ 18 * Patient presents with acute (≤14 days) occlusion of lower limb artery(ies) (below inguinal ligament) * Patient with a Rutherford Category I, IIa or IIb score * Frontline treatment with Indigo Aspiration System * Informed consent is obtained from either patient or legally authorized representative (LAR) Exclusion Criteria: * Life expectancy \<1 year * Vessel size \<2 mm * LE ALI secondary to dissections, vasculitis, and/or target vessel trauma * Amputation in the ipsilateral limb * Pregnancy or positive pregnancy test according to site specific standards of care (only required for women of child bearing potential, serum or urine acceptable) * Absolute contraindication to contrast administration * Patient is unwilling or unable to comply with protocol follow up schedule and/or based on the Investigator's judgment the patient is not a good study candidate * Currently participating in an investigational drug or device clinical trial that may confound the study endpoints. Patients in observational, natural history, and/or epidemiological studies not involving intervention are eligible.