This clinical study will assess the safety and immunogenicity of 2 dose levels of mRNA-1653, a combined human metapneumovirus and human parainfluenza virus type 3 vaccine, in healthy adults (18 to 49 years of age) and 2 dose levels in children (12 to 59 months of age) with serologic evidence of prior exposure. The safety profile of the adult cohort will permit enrollment of the pediatric cohort.
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Proportion of Participants with Solicited Local and Systemic Adverse Reactions (ARs)
Timeframe: Up to 7 days after each dose administration
Proportion of Participants with Unsolicited Adverse Events (AEs)
Timeframe: Up to 28 days after each dose administration
Proportion of Participants with Serious Adverse Events (SAEs) and Medically-Attended AEs
Timeframe: Up to 1 year after the last dose administration