The primary objectives of the study are: * To describe the safety profile of each of the 3 dosages of vYF and of YF-VAX® within the 28 days post-vaccination and up to the 6 months (Day 180) post-vaccination visit * To describe the antibody responses elicited by each of the 3 dosages of vYF and by YF-VAX on Day 0 pre-vaccination and then on Day 10, Day 14, Day 28 and 6 months (Day 180) post-vaccination overall and by baseline flavivirus serostatus * To quantify the detectable yellow fever (YF) vaccinal viremia in each vaccine groups (vYF and YF-VAX) in a subset of subjects on Day 0 visit, Day 1 visit, Day 3 visit, Day 5 visit, Day 7 visit, Day 10 visit, and Day 14 visit.
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Number of participants with immediate adverse events
Timeframe: Within 30 minutes after vaccination
Number of participants with solicited injection site reactions
Timeframe: Within 7 days after vaccination
Number of participants with solicited systemic reactions
Timeframe: Within 14 days after vaccination
Number of participants with unsolicited adverse events
Timeframe: Within 28 days after vaccination
Number of participants with Grade 3 fever
Timeframe: Within 28 days after vaccination
Number of participants with serious adverse events
Timeframe: From Day 0 to Day 180
Number of participants with hematology and biochemistry out-of-range test results
Timeframe: From Day 0 to Day 14
Number of participants with YF and flavivirus viremia and out-of-normal-range biological test results in the event of severe fever, or suspicion of neurotropic disease or acute viscerotropic diseases
Timeframe: Within 28 days after vaccination
Number of participants with seroconversion to YF virus
Timeframe: From Day 0 to Day 28
Number of participants with neutralizing antibody titers against YF virus above pre-defined threshold
Timeframe: From Day 0 to Day 180
Geometric mean titers of neutralizing antibodies against YF virus
Timeframe: From Day 0 to Day 180
Number of participants with YF vaccinal viremia
Timeframe: From Day 0 to Day 14
Level of YF vaccinal viremia
Timeframe: From Day 0 to Day 14