The primary objectives of the study are: * To describe the safety profile of each of the 3 dosages of vYF and of YF-VAX® within the 28 days post-vaccination and up to the 6 months (Day 180) post-vaccination visit * To describe the antibody responses elicited by each of the 3 dosages of vYF and by YF-VAX on Day 0 pre-vaccination and then on Day 10, Day 14, Day 28 and 6 months (Day 180) post-vaccination overall and by baseline flavivirus serostatus * To quantify the detectable yellow fever (YF) vaccinal viremia in each vaccine groups (vYF and YF-VAX) in a subset of subjects on Day 0 visit, Day 1 visit, Day 3 visit, Day 5 visit, Day 7 visit, Day 10 visit, and Day 14 visit.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Number of participants with immediate adverse events
Timeframe: Within 30 minutes after vaccination
Number of participants with solicited injection site reactions
Timeframe: Within 7 days after vaccination
Number of participants with solicited systemic reactions
Timeframe: Within 14 days after vaccination
Number of participants with unsolicited adverse events
Timeframe: Within 28 days after vaccination
Number of participants with Grade 3 fever
Timeframe: Within 28 days after vaccination
Number of participants with serious adverse events
Timeframe: From Day 0 to Day 180
Number of participants with hematology and biochemistry out-of-range test results
Timeframe: From Day 0 to Day 14
Number of participants with YF and flavivirus viremia and out-of-normal-range biological test results in the event of severe fever, or suspicion of neurotropic disease or acute viscerotropic diseases
Timeframe: Within 28 days after vaccination
Number of participants with seroconversion to YF virus
Timeframe: From Day 0 to Day 28
Number of participants with neutralizing antibody titers against YF virus above pre-defined threshold
Timeframe: From Day 0 to Day 180
Geometric mean titers of neutralizing antibodies against YF virus
Timeframe: From Day 0 to Day 180
Number of participants with YF vaccinal viremia
Timeframe: From Day 0 to Day 14
Level of YF vaccinal viremia
Timeframe: From Day 0 to Day 14