Objective of this study is to investigate the bystanders' exposure to e-cigarette emissions in controlled conditions in confined settings. Design: a cross-sectional experimental study developed in two settings: a car and a room. The experimental study will be replicated 5 times in each setting. Three volunteers will be enrolled: 2 non-users of e-cigarettes (and non-smokers of any tobacco or nicotine product) and 1 exclusive e-cigarette user (not using any other tobacco or nicotine product) to create aerosol. In brief, during the experimental session the e-cigarette user will be asked to use electronic cigarette during 30 minutes and two non-smokers will sit next to the user. Individual exposure will be measured through saliva sample collection and irritation symptoms questionnaire to be collected 4 times: before exposure, just after 30 minutes of exposure, 30 minutes after the end of exposure and 3 hours after the end of exposure. Moreover, environmental exposure will be measured prior (5 min), during (30 min) and after (5 min) the exposure; particulate matter and airborne nicotine concentrations will be measure for this purpose.
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Change in airborne nicotine concentration (mg/m3)
Timeframe: Pre-exposure (5 minutes*5 replications in two settings: car and room); concentration during the exposure (30 minutes*5 replications in two settings: car and room); Post-exposure (5 minutes*5 replications in two settings: car and room)