Electronic nicotine delivery systems (ENDS) are a rapidly growing global epidemic among adolescents and young adults. Unlike other ENDS such as e-cigarettes, e-hookahs are used through traditional water-pipes, allowing the vapor-containing nicotine, propylene glycol, glycerin, and flavorings-to pass through a water-filled basin, potentially altering the vapor, before it is inhaled through the user's mouth. Contributing to e-hookahs popularity is the belief that the flavored smoke is detoxified as it passes through the water-filled basin, rendering e-hookah a safer tobacco alternative. However, an e-hookahs deliver flavored nicotine by creating a vapor of fine particles and volatile organic compounds that could induce vascular toxicity. While e-hookah vaping acutely reduces endothelial function, the specific role of nicotine and the mechanisms by which it may impairs endothelial function remain understudied. The objective of this project is to investigate the specific role of nicotine in mediating the acute effects of e-hookah vaping on endothelial dysfunction.
Age range
21 Years – 39 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Flow-Mediated Dilation (FMD)
Timeframe: Changes pre- and post- the 30-minute smoking or vaping exposure sessions
Acetylcholine-stimulated nitric oxide production
Timeframe: Changes pre- and post- the 30-minute smoking or vaping exposure sessions
Basal reactive oxygen species bioactivity
Timeframe: Changes pre- and post- the 30-minute smoking or vaping exposure sessions
Fibrinogen levels
Timeframe: Changes pre- and post- the 30-minute smoking or vaping exposure sessions
Heme oxygenase-1 assay
Timeframe: Changes pre- and post- the 30-minute smoking or vaping exposure sessions
paraoxonase-1 activity
Timeframe: Changes pre- and post- the 30-minute smoking or vaping exposure sessions
HDL protection assay
Timeframe: Changes pre- and post- the 30-minute smoking or vaping exposure sessions
Nicotine levels
Timeframe: Changes pre- and post- the 30-minute smoking or vaping exposure sessions
Carbon monoxide levels
Timeframe: Changes pre- and post- the 30-minute smoking or vaping exposure sessions