Curcumin and Exercise in Chronic Kidney Disease

Inclusion Criteria for CKD subjects: Age 45-80 years old CKD stage III and IV (estimated glomerular filtration rate: 15-60 mL/min/1.73m2) BMI \<40 kg/m2-1 Able to give informed consent Exclusion Criteria for CKD subjects will include answering yes to the following questions: * Active participation in another study? * Dialysis? * End stage renal disease or kidney failure? * Kidney transplant? * Sever liver disease or transplant? * Diabetes? * Angina (i.e., chest discomfort/pain/pressure upon exertion) * Severe congestive heart failure? * Pacemaker/defibrillator? * Heart arrhythmia (i.e. Atrial fibrillation/flutter)? * Pregnant, breastfeeding, or unwilling to use adequate birth control? * Active infection or antibiotic therapy? * Immunosuppressive therapy within the last 3 months? * History of stroke? * Have you had a heart attack in the last 3 months? * Have you taken curcumin in last 3 months? * Current use of Hormone Replacement Therapy (if female)? * Current smoker? * Anemic (Hemoglobin count \<9)? Inclusion Criteria for healthy middle-age and older subjects: Age 45-80 years old BMI \<40 kg/m2 1 Able to give informed consent Exclusion Criteria for health older subjects will include answering yes to the following questions: * Chronic kidney disease? * Hypertension? * Asthma? * Heart disease? * Clinical depression? * Autonomic disorders? * Sleep apnea? * Sever liver disease or transplant? * Diabetes? * Heart attack? * Angina (i.e., chest discomfort/pain/pressure upon e…