Noninvasive VNS to Facilitate Excitability in Motor Cortex (NCT04130646) | Clinical Trial Compass
CompletedNot Applicable
Noninvasive VNS to Facilitate Excitability in Motor Cortex
United States12 participantsStarted 2020-03-15
Plain-language summary
Transcranial Magnetic Stimulation (TMS) positively influences motor rehabilitation in stroke recovery. Transcutaneous auricular vagus nerve stimulation (taVNS) has shown effects on cortical plasticity. We investigate whether combination of TMS and taVNS is more effective at motor cortex excitability than either modality alone.
Who can participate
Age range18 Years – 65 Years
SexALL
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Inclusion Criteria:
* Age 18-80
* endorsing good health
Exclusion Criteria:
* no TMS-induced motor cortex excitability changes in response to 20Hz motor cortex rTMS
* active psychiatric or neurological disorders
* history of CNS disease, concussion, overnight hospitalization, or other neurologic sequelae, tumors, seizures, frequent or severe headaches
* metal implanted above the neck
* currently taking seizure reducing medications
* currently taking psychotropic medications
* any psychotropic medication taken within 5 half-lives of procedure time
* abuse or dependence of drugs (excluding nicotine and caffeine)
* currently taking medications that lower the seizure threshold
* taking any of the stimulants, thyroid medication, or steroids
* implanted devices/ferrous metal of any kind
* history of seizure or seizure disorder
* inability to determine motor threshold.
* Pregnant females and children under the age of 18 will be excluded for safety reasons
* No vulnerable populations or special classes of subjects will be considered for participation.
What they're measuring
1
Safety of Combined taVNS and TMS
Timeframe: every 10 minutes following for 30 minutes