This study will evaluate the application of hAM at the time of cardiac surgery to decrease inflammation and the subsequent substrate to reduce incidence of post-operative atrial fibrillation. Patients will randomized 1:1 to receive either hAM application or standard of care.
Age range
18 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Number of Participants With Adverse Events
Timeframe: 1 month
Number of Participants With Post Op Atrial Fibrillation Between Patients Who Receive hAM and Controls
Timeframe: 1 month
proBNP (Serum) Between Groups at Time of Surgery
Timeframe: Surgery
C-reactive Protein (Serum) Between Groups at Time of Surgery
Timeframe: Surgery
Interleukin-6 (Serum) Between Groups at Time of Surgery
Timeframe: Surgery
Tumor Necrosis Factor - Alpha (TNFa; Serum) Between Groups at Time of Surgery
Timeframe: Surgery
proBNP (Serum) Between Groups at 24 Hours Post-op
Timeframe: 24 hours
C-reactive Protein (Serum) Between Groups at 24-hours Post-op
Timeframe: 24 hours
Interleukin-6 (Serum) Between Groups at 24-hours Post-op
Timeframe: 24 hours
Tumor Necrosis Factor - Alpha (TNFa; Serum) Between Groups at 24 Hours Post-op
Timeframe: 24 hours
proBNP (Serum) Between Groups at 48 Hours Post-op
Timeframe: 48 hours
C-reactive Protein (Serum) Between Groups at 48 Hours Post-op
Timeframe: 48 hours
Interleukin-6 (Serum) Between Groups at 48 Hours Post-op
Timeframe: 48 hours
Tumor Necrosis Factor - Alpha (Serum) Between Groups at 48 Hours Post-op
Timeframe: 48 hours
proBNP (Serum) Between Groups at 72 Hours Post-op
Timeframe: 72 hours
CRP (Serum) Between Groups at 72 Hours Post-op
Timeframe: 72 hours
Interleukin-6 (Serum) Between Groups at 72 Hours Post-op
Timeframe: 72 hours
TNFa (Serum) Between Groups at 72 Hours Post-op
Timeframe: 72 hours
proBNP (Serum) Between Groups at Follow-up
Timeframe: 1 month
CRP (Serum) Between Groups at Follow-Up
Timeframe: 1 month
Interleukin-6 (Serum) Between Groups at Follow-up
Timeframe: 1 month
TNFa (Serum) Between Groups at Follow-up
Timeframe: 1 month
proBNP (Pericardial Fluid) Between Groups at Time of Surgery
Timeframe: Surgery
C-reactive Protein (Pericardial Fluid) Between Groups at Time of Surgery
Timeframe: Surgery
Interleukin-6 (Pericardial Fluid) Between Groups at Time of Surgery
Timeframe: Surgery
Tumor Necrosis Factor - Alpha (Pericardial Fluid) Between Groups at Time of Surgery
Timeframe: Surgery
proBNP (Pericardial Fluid) Between Groups at 24 Hours Post-op
Timeframe: 24 hours
C-reactive Protein (Pericardial Fluid) Between Groups at 24 Hours Post-op
Timeframe: 24 hours
Interleukin-6 (Pericardial Fluid) Between Groups at 24 Hours Post-op
Timeframe: 24 hours
Tumor Necrosis Factor - Alpha (Pericardial Fluid) Between Groups at 24 Hours Post-op
Timeframe: 24 hours
proBNP (Pericardial Fluid) Between Groups at 48 Hours Post-op
Timeframe: 48 hours
C-reactive Protein (Pericardial Fluid) Between Groups at 48 Hours Post-op
Timeframe: 48 hours
Interleukin-6 (Pericardial Fluid) Between Groups at 48 Hours Post-op
Timeframe: 48 hours
Tumor Necrosis Factor - Alpha (Pericardial Fluid) Between Groups at 48 Hours Post-op
Timeframe: 48 hours
proBNP (Pericardial Fluid) Between Groups at 72 Hours Post-op
Timeframe: 72 hours
C-reactive Protein (Pericardial Fluid) Between Groups at 72 Hours Post-op
Timeframe: 72 hours
Interleukin-6 (Pericardial Fluid) Between Groups at 72 Hours Post-op
Timeframe: 72 hours
Tumor Necrosis Factor - Alpha (Pericardial Fluid) Between Groups at 72 Hours Post-op
Timeframe: 72 hours