This study will evaluate the application of hAM at the time of cardiac surgery to decrease inflammation and the subsequent substrate to reduce incidence of post-operative atrial fibrillation. Patients will randomized 1:1 to receive either hAM application or standard of care.
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Number of Participants With Adverse Events
Timeframe: 1 month
Number of Participants With Post Op Atrial Fibrillation Between Patients Who Receive hAM and Controls
Timeframe: 1 month
proBNP (Serum) Between Groups at Time of Surgery
Timeframe: Surgery
C-reactive Protein (Serum) Between Groups at Time of Surgery
Timeframe: Surgery
Interleukin-6 (Serum) Between Groups at Time of Surgery
Timeframe: Surgery
Tumor Necrosis Factor - Alpha (TNFa; Serum) Between Groups at Time of Surgery
Timeframe: Surgery
proBNP (Serum) Between Groups at 24 Hours Post-op
Timeframe: 24 hours
C-reactive Protein (Serum) Between Groups at 24-hours Post-op
Timeframe: 24 hours
Interleukin-6 (Serum) Between Groups at 24-hours Post-op
Timeframe: 24 hours
Tumor Necrosis Factor - Alpha (TNFa; Serum) Between Groups at 24 Hours Post-op
Timeframe: 24 hours
proBNP (Serum) Between Groups at 48 Hours Post-op
Timeframe: 48 hours
C-reactive Protein (Serum) Between Groups at 48 Hours Post-op
Timeframe: 48 hours
Interleukin-6 (Serum) Between Groups at 48 Hours Post-op
Timeframe: 48 hours
Tumor Necrosis Factor - Alpha (Serum) Between Groups at 48 Hours Post-op
Timeframe: 48 hours
proBNP (Serum) Between Groups at 72 Hours Post-op
Timeframe: 72 hours
CRP (Serum) Between Groups at 72 Hours Post-op
Timeframe: 72 hours
Interleukin-6 (Serum) Between Groups at 72 Hours Post-op
Timeframe: 72 hours
TNFa (Serum) Between Groups at 72 Hours Post-op
Timeframe: 72 hours
proBNP (Serum) Between Groups at Follow-up
Timeframe: 1 month
CRP (Serum) Between Groups at Follow-Up
Timeframe: 1 month
Interleukin-6 (Serum) Between Groups at Follow-up
Timeframe: 1 month
TNFa (Serum) Between Groups at Follow-up
Timeframe: 1 month
proBNP (Pericardial Fluid) Between Groups at Time of Surgery
Timeframe: Surgery
C-reactive Protein (Pericardial Fluid) Between Groups at Time of Surgery
Timeframe: Surgery
Interleukin-6 (Pericardial Fluid) Between Groups at Time of Surgery
Timeframe: Surgery
Tumor Necrosis Factor - Alpha (Pericardial Fluid) Between Groups at Time of Surgery
Timeframe: Surgery
proBNP (Pericardial Fluid) Between Groups at 24 Hours Post-op
Timeframe: 24 hours
C-reactive Protein (Pericardial Fluid) Between Groups at 24 Hours Post-op
Timeframe: 24 hours
Interleukin-6 (Pericardial Fluid) Between Groups at 24 Hours Post-op
Timeframe: 24 hours
Tumor Necrosis Factor - Alpha (Pericardial Fluid) Between Groups at 24 Hours Post-op
Timeframe: 24 hours
proBNP (Pericardial Fluid) Between Groups at 48 Hours Post-op
Timeframe: 48 hours
C-reactive Protein (Pericardial Fluid) Between Groups at 48 Hours Post-op
Timeframe: 48 hours
Interleukin-6 (Pericardial Fluid) Between Groups at 48 Hours Post-op
Timeframe: 48 hours
Tumor Necrosis Factor - Alpha (Pericardial Fluid) Between Groups at 48 Hours Post-op
Timeframe: 48 hours
proBNP (Pericardial Fluid) Between Groups at 72 Hours Post-op
Timeframe: 72 hours
C-reactive Protein (Pericardial Fluid) Between Groups at 72 Hours Post-op
Timeframe: 72 hours
Interleukin-6 (Pericardial Fluid) Between Groups at 72 Hours Post-op
Timeframe: 72 hours
Tumor Necrosis Factor - Alpha (Pericardial Fluid) Between Groups at 72 Hours Post-op
Timeframe: 72 hours