Pilot Project: The Amplicon and Metatranscriptomic Study of Intra and Extra Intestinal Microbiome in Non-infectious Uveitis Disease

Inclusion Criteria: * New patient registered at Cipto Mangunkusumo Hospital since November 2019 * Patient diagnosed with non-infectious uveitis (with Behcet, VKH history) * Patient idiopathic uveitis (proven to have negative result by available etiological uveitis work-ups) * Minimum age: 18 years old * Experience active inflammation in the past 180 days and or during patient registration following Standard Uveitis Nomenclature (SUN) guidelines, in at least: * equal and or more than 2+ anterior chamber cells * equal and or more than 2+ vitreous haze and/or * active retinal/choroidal lesions Exclusion Criteria: * patients had taken probiotics supplement or antibiotics 3 months before sample collection * or who experience prolonged diarrhea or constipation * or undergone gastrointestinal surgery * having any form of malignancy * having a systemic disease such as hypertension, obesity, inflammatory bowel disease, or diabetes. * Disagree to sign informed consent * Uveitis is proven to be an infectious origin * Pregnant patient * Loss to follow up patient Healthy volunteers are recruited for this study after giving consent with the following inclusion criteria: * age: 18-50 years old (Man/Woman) * having no health complaints or symptoms * not in any long term medications * having no history of allergy * willing to cooperate in the study * state of complete physical, mental and social well being