This study investigates the effect of lactate infusion on epileptic discharges on EEG and seizure frequency in glucose transporter 1 deficiency syndrome (GLUT1DS) patients.
Who can participate
Age range6 Years – 18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Diagnosed with GLUT1DS and known in our center.
* Baseline characteristics include a high frequency of clinical seizures and epileptic discharges on EEG.
* History of trying ketogenic diet with good compliance without beneficial effects.
* Age \> 6 years.
* Informed consent.
Exclusion Criteria:
* Additional medical condition or illness that impairs the patient's ability to participate in the study (for example actual treatment of a malignancy, active infection, poorly controlled diabetes mellitus, hypertension, organ failure, clinically significant haematological or biochemical abnormalities).
* Elevated serum sodium (\> 145 mmol/L).
* Participation in another interventional study at start of the study or during the study.
* Presence of known panic disorders or a history of panic attacks.
What they're measuring
1
Number of changes in epileptic discharges on EEG during the infusion of lactate.