Nicotinamide Riboside as an Enhancer of Exercise Therapy in Hypertensive Older Adults (The NEET Trial)

Inclusion Criteria: * Age 55 years and older * Daytime average of systolic blood pressure of ≥ 130 mmHg and \< 160 mmHg. * Sedentary lifestyle, defined as \< 150 min/wk of moderate physical activity as assessed by the CHAMPS questionnaire. * Willingness to be randomized to either treatment group * Willingness to participate in all study procedures Exclusion Criteria: * Failure to provide informed consent. * Pregnant * Change in blood pressure therapy (type or dose) within the last 3 months- Temporary Exclusion * Daytime average of systolic blood pressure ≥160 mmHg. * Regular consumption of nicotinamide riboside supplement * Current involvement in supervised rehabilitation program * Absolute contraindication(s) to exercise training according to American College of Sports Medicine guidelines \[11\] * Daytime average of systolic blood pressure below 130mm Hg or Diastolic BP ≥ 100mm Hg. * Peripheral vascular disease; peripheral neuropathy; retinopathy * Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina; * Myocardial infarction or stroke within past year * Significant cognitive impairment, including known dementia diagnosis or a Mini-Mental State Examination exam score \< 24 * Progressive, degenerative neurologic disease, e.g., Parkinson's Disease, multiple sclerosis; * Severe rheumatologic or orthopedic diseases, e.g., awaitin…