Effects of Low Dose Ozone on Airway Inflammatory Responses in Adults With Asthma - Sedentary Nasal Ozone (Asthma SNOZ)

Inclusion Criteria: * Ages 18-45, both sexes included * Mild intermittent asthma, defined as daytime asthma symptoms no more than 2 times per week, night time asthma symptoms no more than 2 times per month, FEV1 \>80% of predicted, and asthma exacerbation requiring oral steroids 1 time or less per year. * Good general health as evidenced by medical history * Vital signs will be within normal limits on admission to the study: oxygen saturation by pulse oximetry (SpO2) \> 94%, systolic blood pressure between 150-90 mm Hg, diastolic blood pressure between 100-60 mm Hg, afebrile. * FEV1 of at least 80% of predicted at baseline * Able to provide informed consent * Proof of Covid Vaccination Exclusion Criteria: * Any chronic medical condition considered by the PI as a contraindication to the exposure study including significant cardiovascular disease, diabetes, chronic renal disease, chronic thyroid disease, history of chronic infections/immunodeficiency, history of tuberculosis * Physician directed emergency treatment for an asthma exacerbation within the preceding 12 months * Orthopedic injuries or impediments that would preclude bicycle or treadmill exercise * Viral upper respiratory tract infection within 4 weeks of challenge. * Any acute infection requiring antibiotics within 4 weeks of exposure or fever of unknown origin within 2 weeks of challenge. * Individuals who use daily controller medication for asthma. Pre-treatment with a short acting bronchodilator prior to exerc…