Allergy Antibiotics And Microbial Resistance

Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study * Male or Female, aged 18 years or above * Current penicillin allergy (or sensitivity) record of any kind in their electronic health record * Receipt of either: penicillin, cephalosporin, tetracycline, quinolone or macrolide class antibiotic or fosfomycin, nitrofurantoin, trimethoprim, clindamycin in the previous 12 months N.B.1 Patients who have been formally tested for penicillin allergy in the past and been found not to be penicillin allergic but still have a medical record indicating a penicillin allergy, are eligible for the trial. Exclusion Criteria: * Life expectancy estimated \<1 year by GP * Unable to attend immunology clinic * Unsuitable for entry into testing pathway because: * Allergy history consistent with anaphylaxis to penicillin * History of toxic epidermal necrolysis, Stevens-Johnson syndrome, Drug reaction with eosinophilia and systemic symptoms (DRESS) or any severe rash which blistered or needed hospital treatment, and acute generalised exanthematous pustulosis precipitated by a penicillin * Has been formally tested for penicillin allergy in the past and been found to be penicillin allergic * History of brittle/severe asthma or has had a course of steroids in the past 3 months for asthma or unstable coronary artery disease, or dermographism or other severe/poorly controlled skin conditions * Considered unsuitable for …