The main goal of the project is to develop multiple noninvasive neuromodulatory strategies to facilitate full weight bearing stepping overground in people with paralysis. We will determine the effectiveness of combining noninvasive spinal cord stimulation and the administration of buspirone (a monoaminergic agonist) in facilitating locomotor activity in a gravity-neutral apparatus, during body weight supported stepping on a treadmill, when stepping overground, or during full weight bearing stepping overground in a rolling walker. Our objective is to identify the experimental variables that define the efficacy of these novel neuromodulatory techniques over a 5 year period in 15 participants with severe spinal cord injury who are at least one year post-injury.
Age range
18 Years – 65 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Lower Extremity Electromyography, change over time
Timeframe: Before and after each study phase, 1 year per group.
Lower Extremity Kinematics, change over time
Timeframe: Before and after each study phase, 1 year per group.
Treadmill Electromyography Assessment, change over time
Timeframe: Before and after each study phase, 1 year per group.
Spinal Pathway Electrophysiology, change over time
Timeframe: Before and after each study phase, 1 year per group.
Voluntary Lower Extremity Angles, change over time
Timeframe: Before and after each study phase, 1 year per group.
Voluntary Lower Extremity Forces, change over time
Timeframe: Before and after each study phase, 1 year per group.
Body Temperature, change over time
Timeframe: Before and after each study phase, 1 year per group.
Blood Pressure, change over time
Timeframe: Before and after each study phase, 1 year per group.
Heart Rate, change over time
Timeframe: Before and after each study phase, 1 year per group.
Respiration Rate, change over time
Timeframe: Before and after each study phase, 1 year per group.
Dual-energy X-ray absorptiometry, change over time
Timeframe: Before and after each study phase, 1 year per group.
Acoustic Gastro-Intestinal Surveillance, change over time
Timeframe: Before and after each study phase, 1 year per group.
Bladder capacity, change over time
Timeframe: Before and after each study phase, 1 year per group.
Urodynamics, change over time
Timeframe: Before and after each study phase, 1 year per group.
Cognitive interference, change over time
Timeframe: Before and after each study phase, 1 year per group.
Assessment of verbal fluency, change over time
Timeframe: Before and after each study phase, 1 year per group.