Optimal Treatment of MRSA Throat Carriers

Inclusion Criteria: * Age ≥ 18 years * MRSA carriage in the throat after first topical decolonization treatment (regardless of previous swab results) * Has completed one standard topical decolonization treatment Exclusion Criteria: * Pregnant or lactating woman * Sexually active women in the reproductive age that do not use approved contraceptives (appendix 4) * Cannot read or speak Danish (the written participant information is in Danish) * Skin infection or other active infections * Activity in skin diseases such as eczema or psoriasis. * MRSA isolate resistant to clindamycin (defined by inhibition zone size \< 22 mm using disk diffusion methodology) or resistant to mupirocin * Allergy to clindamycin, chlorhexidine or mupirocin * Taking medications that interact with clindamycin according to the medicine information leaflet. * MRSA active antibiotic treatment within 7 days before inclusion in the study or during study period * Followed by specialist due to liver disease * Severe overweight (BMI \> 35) or weight \< 50 kg * Indwelling percutaneous permanent devices such as intravenous catheters or urinary tract catheters * Daily contact with pigs or minks (decolonization therapy is generally not offered, according to The National Board of Health) * Nursing home resident or health care worker (they have a more frequent control swab regime) * Not being capable of completing another treatment successfully * MRSA positive household members younger than 2 years (MRSA positive c…