The purpose of this study is to evaluate the bioequivalence of isavuconazole following a single dose of isavuconazonium sulfate intravenous (IV) solution via nasogastric (NG) tube (test formulation) compared to a single dose of isavuconazonium sulfate capsules for oral administration (i.e., oral capsules administered to nonintubated participants)(reference formulation). In addition, this study will evaluate the safety and tolerability of isavuconazole and the general pharmacokinetic (PK) parameters of isavuconazole when administered as a single dose of isavuconazonium sulfate IV solution via NG tube (test formulation) and a single dose of isavuconazonium sulfate capsules for oral administration (i.e., oral capsules administered to nonintubated participants) (reference formulation) under fasting conditions in healthy male and female participants.
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Pharmacokinetics (PK) of isavuconazole in plasma: area under the concentration-time curve from the time of dosing extrapolated to time infinity (AUCinf)
Timeframe: Predose on Day 1 and up to Day 21 postdose in each period
PK of isavuconazole in plasma: area under the concentration-time curve from 0 to 72 hours (AUC72)
Timeframe: Predose on Day 1 and up to Day 3 postdose in each period
PK of isavuconazole in plasma: area under the concentration-time curve from the time of dosing to the last measurable concentration (AUClast)
Timeframe: Predose on Day 1 and up to Day 21 postdose in each period
PK of isavuconazole in plasma: maximum concentration (Cmax)
Timeframe: Predose on Day 1 and up to Day 21 postdose in each period