Optimize PRO Study

Inclusion Criteria: * Acceptable candidate for treatment with the Evolut™ PRO or Evolut™ PRO+ system (FX system for the addendum where applicable) in accordance with the Instructions for Use and local regulations; * Subject is symptomatic from his/her aortic valve stenosis, as demonstrated by New York Heart Association (NYHA) Functional Class II or greater; * Subject and the treating physician agree that the subject will return for all required post procedure follow-up visits; * Anatomically suitable for transfemoral TAVR with the Medtronic TAVR system; * Subject meets the legal minimum age to provide Informed Consent based on local regulatory requirements. Exclusion Criteria: * Contraindicated for treatment with the Evolut™ PRO or Evolut™ PRO+ or FX system (where applicable) in accordance with the Instructions for Use * Anatomically not suitable for the Evolut™ PRO or Evolut™ PRO+ or FX system (where applicable); * Previous aortic valve replacement * Reduced ventricular function with left ventricular ejection fraction (LVEF) \<35% as measured by resting echocardiogram; * Frailty assessments identify: * Subject is \<80 years of age and three or more of the following apply; OR subject is \> 80 years of age and two or more of the following apply * Wheelchair bound * Resides in an institutional care facility (e.g. nursing home, skilled care center) * Body Mass Index \<20kg/m2 * Grip strength \<16kg * Katz Index score ≤4 * Albumin \<3.5 g/dL * Bicus…