CompletedNot Applicable

Endocrinological Profile in Patients With Medication-overuse Headache Before and After Withdrawal Therapy

Denmark50 participantsStarted 2019-08-01

Plain-language summary

The project will be conducted to investigate the hormonal homeostasis in men and women, with a special emphasis on sex hormones in men and AMH level in women, before and after withdrawal of the overused analgesics among MOH patients. Additionally, a more broad endocrine profile will be explored before and after withdrawal. It is hypothesized that patients with MOH have disturbed hormone levels, which is normalized after withdrawal of the medication-overuse.

Who can participate

Age range18 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Confirmed MOH diagnosis according to the ICHD-III (1). * Capable of completing headache diary and headache calendar * Age 18-60 years old for men and 18-50 years old for women * Signed informed consent * BMI 19-30 Exclusion Criteria: * Severe physical illness * Severe psychiatric disorders requiring pharmacological treatment * Addiction to alcohol or other drugs * Pregnancy or breastfeeding * Menopause, either natural or surgical (only women) * Inability to provide reliable information about medical history

What they're measuring

Comparison of levels of following circulating and excreted hormones in the pituitary-gonadal axis at baseline and after 2 months of withdrawal

Timeframe: From baseline to 2 months follow-up

Trial details

NCT IDNCT04090333

SponsorDanish Headache Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-09-01

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