EAdi as a Predictor of Successful Extubation in Patients With Traumatic Cervical Spinal Cord Injury (NCT04089956) | Clinical Trial Compass
CompletedNot Applicable
EAdi as a Predictor of Successful Extubation in Patients With Traumatic Cervical Spinal Cord Injury
China107 participantsStarted 2014-06-01
Plain-language summary
Esophageal recordings of diaphragm electrical activity (EAdi) made it possible to monitor respiratory drive and the subsequent phrenic nerve conduction and respiratory neuromuscular function continuously. Thus, we designed a "spontaneous breathing challenge" test to monitor the change in EAdi after a maximal inspiration. We hypothesized that the absolute change (ΔEAdi) and the percentage changes change (ΔEAdi%) in EAdi after a "spontaneous breathing challenge" predict successful extubation in traumatic CSCI patients during acute hospitalization.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. age 18 years or older
✓. Traumatic CSCI patients with a neurologic level of injury of C1 to C8 by the American Spinal Injury Association (ASIA) standard impairment scale grade A to D
✓. patients with mechanical ventilation due to acute respiratory failure and admit to ICU
✓. with dedicated nasogastric tube with nine electrodes that allow to continuously measure diaphragm electrical activity (EAdi catheter, Maquet, Solna, Sweden) in position.
Exclusion criteria
✕. tracheostomy before ICU admission
✕. withhold or withdraw life sustaining treatment due to other serious organ injury
✕. can't complete instructional actions,
✕. death occurred within 7 days after injury
✕. postoperative MV was a direct result of surgery and had duration of less than 24 hours postoperatively.