A Pharmacokinetic Study of Zolbetuximab (IMAB362) in Chinese Subjects with Locally Advanced Unresectable or Metastatic Gastric or Gastro-esophageal Junction (GEJ) Adenocarcinoma
Age range
18 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Pharmacokinetics (PK) of zolbetuximab: Area under the concentration-time curve (AUC) from the time of dosing extrapolated to time infinity (AUCinf)
Timeframe: Up to 15 months
PK of zolbetuximab: Percentage of AUCinf (AUCinf (%extrap))
Timeframe: Up to 15 months
PK of zolbetuximab: AUC from the time of dosing to the last measurable concentration (AUClast)
Timeframe: Up to 15 months
PK of zolbetuximab: AUC from the time of dosing to the start of the next dosing interval (AUCtau)
Timeframe: Up to 15 months
PK of zolbetuximab: Maximum concertation (Cmax)
Timeframe: Up to 15 months
PK of zolbetuximab: Concentration immediately prior to dosing at multiple dosing (Ctrough)
Timeframe: Up to 15 months
PK of zolbetuximab: Time of the maximum concentration (tmax)
Timeframe: Up to 15 months
PK of zolbetuximab: Terminal elimination half-life (t1/2)
Timeframe: Up to 15 months
PK of zolbetuximab: Time of the last measurable concentration (tlast)
Timeframe: Up to 15 months
PK of zolbetuximab: Clearance (CL)
Timeframe: Up to 15 months
PK of zolbetuximab: Apparent volume of distribution during the terminal phase (Vz)
Timeframe: Up to 15 months
PK of zolbetuximab: Accumulation ratio calculated using AUC (Rac(AUC))
Timeframe: Up to 15 months
PK of zolbetuximab: Rac (Cmax)
Timeframe: Up to 15 months
Number of participants with adverse events (AEs)
Timeframe: Up to 15 months
Number of participants with laboratory test abnormalities and/or AEs
Timeframe: Up to 13 months
Number of participants with body weight abnormalities and/or AEs
Timeframe: Up to 13 months
Number of participants with vital sign abnormalities and/or AEs
Timeframe: Up to 13 months
Number of participants with 12-lead electrocardiogram (ECG) abnormalities and/or AEs
Timeframe: Up to 13 months
Eastern Cooperative Oncology Group (ECOG) performance status score
Timeframe: Up to 13 months