Heroin addiction is a serious problem and the relapse rate of existing treatment methods is extremely high. Recently, international journals such as Science reported that repetitive transcranial magnetic stimulation (rTMS) can reduce the craving of addicts, alleviate depression and anxiety symptoms, and is expected to become an effective treatment. Our preliminary experiment using rTMS to stimulate the left dorsolateral prefrontal cortex of heroin addicts also showed similar effects, however, the mechanism is unclear. Previously, the investigators found that the functional connectivity between left executive control network and default mode network was negatively correlated relapse behavior, while the functional connectivity between salience network and default mode network was positively correlated with relapse behavior. Studies have shown that dopamine dysfunction in addicts and brain metabolism is the biological basis of network connectivity. It suggests that elucidating the relationship between the characteristics of large brain network connectivity and the level of dopamine receptor and relapse behavior in addicts is hopeful to further understand the neurological mechanism of rTMS treatment for addiction. In this project, the investigators intend to observe the changes of brain network connectivity, glucose metabolism and dopamine D2 receptor before and after rTMS treatment in addicts from the perspective of large brain network by combining PET/MRI with psychobehavioral approach. The relationship between rTMS and relapse behavior will be deeply analyzed to provide scientific basis for the development of effective treatment programs.
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Change of craving
Timeframe: Baseline, 1 week later, 1,2,3,4,5,6 months later
Change of protracted-abstinence symptoms
Timeframe: Baseline, 1 week later, 1,2,3,4,5,6 months later
Change of depress symptoms
Timeframe: Baseline, 1 week later, 1,2,3,4,5,6 months later
Change of anxiety symptoms
Timeframe: Baseline, 1 week later, 1,2,3,4,5,6 months later
Change of impulsive behaviors
Timeframe: Baseline, 1 week later, 1,2,3,4,5,6 months later
Change of sleep
Timeframe: Baseline, 1 week later, 1,2,3,4,5,6 months later
Change of functional connectivity between dorsolateral prefrontal cortex and whole brain
Timeframe: Baseline, 1 week later, 1,3,6 months later
Change of gray matter volume of whole brain
Timeframe: Baseline, 1 week later, 1,3,6 months later
Change of white matter integrity of whole brain
Timeframe: Baseline, 1 week later, 1,3,6 months later
Change of availability of dopamine 2 receptor of whole brain
Timeframe: Baseline, 1 month later
Change of metabolism of glucose in the brain
Timeframe: Baseline, 1 month later