Iron deficiency anemia (IDA) is common during pregnancy and has adverse effects on the mother, fetus and newborn. Oral iron supplements are usually recommended to prevent ID/IDA during pregnancy. The aim of this study is to define an iron supplementation schedule with maximal absorption using serum hepcidin profiles and stable iron isotopes in pregnant women. In this randomized, open-label trial, fractional and total iron absorption will be compared from daily dosing with 60 mg iron versus alternate day and every third day dosing with 120 mg iron in pregnant Thai women with low iron stores (n=28) during their second trimester of pregnancy. This study could have wide impact, providing the evidence base for revised, improved recommendations for iron supplementation during pregnancy.
Age range
18 Years – 45 Years
Sex
FEMALE
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The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Fractional iron absorption in %
Timeframe: Day 18
Fractional iron absorption in %
Timeframe: Day 35
Fractional iron absorption in %
Timeframe: Day 53
Total iron absorption in %
Timeframe: Day 18
Total iron absorption in %
Timeframe: Day 35
Total iron absorption in %
Timeframe: Day 53
Serum Hepcidin
Timeframe: Day 1
Serum Hepcidin
Timeframe: Day 2
Serum Hepcidin
Timeframe: Day 4
Serum Hepcidin
Timeframe: Day 18
Serum Hepcidin
Timeframe: Day 19
Serum Hepcidin
Timeframe: Day 21
Serum Hepcidin
Timeframe: Day 35
Serum Hepcidin
Timeframe: Day 36
Serum Hepcidin
Timeframe: Day 39
Serum Hepcidin
Timeframe: Day 53