Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in… (NCT04071574) | Clinical Trial Compass
CompletedPhase 1/2
Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility
Lebanon200 participantsStarted 2018-02-01
Plain-language summary
The study will describe the effectiveness of ovarian stimulation in correlation with female infertility causes in a Lebanese population: a comparative study using 5 protocols of ovulation induction (treatment with "A" gonadotropins alone, "B" short GnRH agonist, "C" multiple-dose GnRH antagonist, "D" long GnRH agonist and "E" combined protocol of GnRH antagonist and agonist) and the outcomes of ICSI. This comparative study will help clinicians to select the relevant protocol of ovarian stimulation related to the female infertility disorders.
Who can participate
Age range21 Years – 44 Years
SexFEMALE
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Inclusion Criteria:
* must not show any of the excluded criteria
* Patients affected by female infertility due to particularly Ovulatory Disorder, Premature Ovarian Failure, Polycystic Ovary Syndrome, Tubal Origin, Ectopic Pregnancy, Salpingitis, Tubal Block/Occlusion, Hydrosalpinx, Cervical/Vaginal, Endocrine, Endometriosis, Fibroids, Congenital Uterine Anomaly, Infections Uterine, and Female Infertility of Other Origin
* The selection of subjects' age must be group matched between protocols of treatment. Premature ovarian failure is defined as AMH (Anti Mullerian Hormone) ≤ 2 ng/mL.
* Willing to collaborate and to attend to the clinical follow-ups for the next three years
* Patients willing to sign informed consent
* Able and willing to comply with all study requirements
* Absence of genetic causes
* Medically suitable to undergo ovarian stimulation
* Normal serum chemistry and hematology screening tests
* Negative human immunodeficiency virus (HIV), hepatitis B (HBV), hepatitis C (HCV) serology
* No history of malignancy
* Complete history \& physical examination
Exclusion Criteria:
* Subjects to be excluded from the study if the male (husband) had any male infertility problem(s)
* Patients with any genetic abnormalities
* Patients with histories of neurologic conditions including moderate or severe head injury, stroke, cerebral or bone damage or malignancies, brain abnormalities, learning disability, major medical or psychiatric illness, and metabolic/cardiovascular di…