Hyoscine Butylbromide for Prevention of Bradycardia During Cesarean Section (NCT04069078) | Clinical Trial Compass
CompletedPhase 4
Hyoscine Butylbromide for Prevention of Bradycardia During Cesarean Section
Egypt173 participantsStarted 2019-10-10
Plain-language summary
The aim of this study is to assess the efficacy of Iv hyoscine butylbromide in preventing Bradycardia during cesarean section under spinal anaesthesia with local anaesthetic and morphine.
Who can participate
Age range18 Years – 40 Years
SexFEMALE
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Inclusion Criteria:
* ASA physical status class I-II.
* Age: 18 Years to 40 Years.
* Women scheduled for elective Cesarean section under spinal anesthesia.
* indications for CS other than fetal or maternal pathology.
Exclusion Criteria:
* Height \< 150 or \> 180 cm
* Body mass index (BMI) \>35 kg/m2
* Contraindication for central neuraxial block
* Refusal to undergo regional anesthesia
* Known allergy to any of the study drugs,
* Infection at the site of injection,
* Coagulopathy,
* Indication to general anesthesia
* Baseline bradycardia (heart rate \< 60/min), or any cardiovascular disease
* Patients taking β-adrenergic blockers or any drugs that may alter normal response to study drugs.
* Arrhythmia such as atrial fibrillation, supraventricular tachycardia, heart block greater than first degree, left bundle branch block,
* Hypertension (systolic blood pressure more than 140 mm Hg or diastolic blood pressure more than 90 mm Hg), unstable angina or cardiomyopathy,
* Associated medical problem with pregnancy (as hypertension, diabetes mellitus, hepatic impairment or renal impairment)