New Biomarkers Associated With the Risk of Premature Delivery.

Inclusion Criteria: * Pregnant women over 18 years of age * Term from 22 to 33 and 6 amenorrhea weeks * Single or twin pregnancy * Emergency consultant, in participating centers, for a threat of premature labor defined by: Uterine contractions greater than or equal to 3 in 30 minutes Clinical modification of the cervix Ultrasound collar less than 25 mm * Free, informed and written consent, dated and signed by the patient and the investigator before any investigation required by the research. * Patient affiliated to a Social Security scheme. Exclusion Criteria: * Premature rupture of membranes * Placenta previa * Vaginal haemorrhage at the time of sampling * Uterine malformation * Strapping, open bite * History of strapping and or open bite * Conization * Fetal malformation * Associated vasorenal pathology * Sexual intercourse less than 24h * Gynecological examination less than 48h * Vaginal treatment in progress * Polyhydramnios * Transfused-transfused syndrome * Twin Anemia Polycythemia syndrome * Fetoscopy during pregnancy