The purpose of this first time-in-human (FTiH) study is to evaluate the safety, reactogenicity and immunogenicity of different dose levels of an experimental rabies glycoprotein G (RG) vaccine (RG-SAM \[CNE\] vaccine), made using a new technology, when administered intramuscularly (IM) on a 0, 2, 6 \*-month schedule to healthy adults. \* There will be no vaccinations with the third dose of any of the study treatments.
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Number of participants reporting solicited local adverse events (AEs) during the 7-day follow-up period after the first dose received in the Primary vaccination phase
Timeframe: During the 7-day follow-up period after the first dose (administered at Day 1)
Number of participants reporting solicited local adverse events (AEs) during the 7-day follow-up period after the second dose received in the Primary vaccination phase
Timeframe: During the 7-day follow-up period after the second dose (administered at Day 61)
Number of participants reporting solicited general AEs during the 7-day follow-up period after the first dose received in the Primary vaccination phase
Timeframe: During the 7-day follow-up period after the first dose (administered at Day 1)
Number of participants reporting solicited general AEs during the 7-day follow-up period after the second dose received in the Primary vaccination phase
Timeframe: During the 7-day follow-up period after the second dose (administered at Day 61)
Number of participants reporting unsolicited AEs during a 30-day follow-up period follow-up after the first dose received in the Primary vaccination phase
Timeframe: During the 30-day follow-up period after the first dose (administered at Day 1).
Number of participants reporting unsolicited AEs during a 30-day follow-up period follow-up after the second dose received in the Primary vaccination phase
Timeframe: During the 30-day follow-up period after the second dose (administered at Day 61).
Number of participants with hematological and biochemical laboratory abnormalities at Day 1.
Timeframe: At Day 1
Number of participants with hematological and biochemical laboratory abnormalities at Day 4.
Timeframe: At Day 4.
Number of participants with hematological and biochemical laboratory abnormalities at Day 8.
Timeframe: At Day 8.
Number of participants with hematological and biochemical laboratory abnormalities at Day 61.
Timeframe: At Day 61.
Number of participants with hematological and biochemical laboratory abnormalities at Day 64.
Timeframe: At Day 64.
Number of participants with hematological and biochemical laboratory abnormalities at Day 68.
Timeframe: At Day 68.
Number of participants reporting medically attended AE (MAEs)
Timeframe: During 90 days (from Day 1 to Day 91)
Number of participants reporting serious adverse events (SAEs)
Timeframe: During 90 days (from Day 1 to Day 91)
Number of participants reporting potential immune-mediated diseases (pIMDs)
Timeframe: During 90 days (from Day 1 to Day 91)