Nobio Clinical Study - Demineralization Prevention With a New Antibacterial Restorative Composite

Inclusion Criteria: * aged between 18 and 80 years, * have at least six natural teeth remaining and have a recent history of dental caries * wearing lower partial denture (with replaced teeth on both sides of the mouth) * willing to wear their denture during the night * are in good health, of either gender * are in good current oral health with no active caries or periodontal disease (but with a history of caries) * have an understanding of the study * have saliva flow within the normal range (stimulated saliva flow rate of greater than 0.7 ml/minute) * no antibiotics for the last three months * willing to comply with all study procedures and protocols, * residing in San Francisco or other nearby locales with community water fluoridation (to eliminate water fluoridation as a potential confounding variable) * able to give written consent themselves * must be able to read and understand English * willing to sign the "Authorization for Release of Personal Health Information and Use of Personally Unidentified Study Data for Research" form; data will only be used for research Exclusion Criteria: * subjects who have less than 6 natural teeth remaining * subjects who have used a 5,000 ppm fluoride toothpaste in the last 6 months * subjects who have used Chlorhexidine or any other antimicrobials (cetylpyridinium etc.) in the last 6 months * show evidence of extremely poor oral hygiene * subjects suffering from systemic diseases, significant past or medical history with conditions …