A Study Evaluating Safety, Pharmacodynamics and Pharmacokinetics of HSK3486 and Etomidate for Induction of Anesthesia in Healthy Male Subjects

Inclusion Criteria: * 1.Male, aged 18 - 49 years (inclusive) * 2.Be in general good health without clinically significant medical history, as determined by the investigator * 3.American Society of Anesthesiologists Physical Status Classification of I or II * 4.Body mass index (BMI) between 18 and 30 kg/m2 (inclusive) * 5.Negative screen for drugs of abuse, alcohol, hepatitis B surface antigen, hepatitis C and Human Immunodeficiency Virus (HIV) at screening; and drugs of abuse, alcohol pre dose on Day -1 * 6.Normal or non-clinically significant findings on a physical examination, 12-lead ECG and vital signs (respiration rate between 12 and 20 breaths per minute, BP between 100-140/50-90 mmHg, heart rate between 45-99 beats per minute, temperature between 35.8 degrees and 37.5 degrees). Pulse oximetry values \>95% on room air. * 7.Clinical laboratory values within the normal limits as defined by the clinical laboratory, unless the investigator decides that out-of-range values are not clinically significant * 8.Ability to provide written informed consent * 9.Willing and able to follow study instructions and likely to complete all study requirements * 10.Suitable venous and arterial access. Exclusion Criteria: * 1.History of allergy or sensitivity to: propofol, etomidate or components of HSK3486 (excipients soy bean oil, glycerine, triglycerides, purified egg phospholipids, sodium oleate and sodium hydroxide), or plain lignocaine * 2.History of clinically significant problems …