PREDICTIVE IMMUNOLOGICAL STUDY OF RECURRENT ABORTIONS AND IMPLANTATION FAILURE (NCT04052438) | Clinical Trial Compass
CompletedNot Applicable
PREDICTIVE IMMUNOLOGICAL STUDY OF RECURRENT ABORTIONS AND IMPLANTATION FAILURE
200 participantsStarted 2015-01
Plain-language summary
The involvement of the immune system in the process of implantation and its modulation as a therapeutic line in these alterations, failure of implantation and repetition abortion are controversial and make it necessary to conduct clinical studies properly led and with a study population chosen by strict criteria in order to better understand the involvement of the different innate and adaptive immune mechanisms in the field of reproductive medicine and especially in clinically expressed failures recurrent implantation failure and recurrent abortions.
Who can participate
Age range
18 Years – 45 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria in recurrent implantation failure:
* Body mass index between 19 and 27 kg/m2
* Patients with 3 or more IVF failures following transfer of good quality embryos or with 2 or more failures following embryo transfer in egg donation cycles.
* At least one embryo transfer is required to have been made in a blastocyst state (embryo on day 5) and with the current partner/donor.
* Study of normal karitype..
* Normal thrombophilia study.
* Vaginal exudate (Chlamydia, ureaplasma) normal
* Normal immune study.
* No hormone treatment in the two months prior to inclusion in the study.
Inclusión criteria in recurrent abortion:
* Body mass index between 19 and 27 kg/m2
* Patients with 3 or more recurrent abortions, natural gestations or after transfer of good quality embryos (own or ovodonation)
* Study of normal karitype.
* Normal thrombophilia study.
* Vaginal exudate (Chlamydia, ureaplasma) normal
* Normal immune study.
* No hormone treatment in the two months prior to inclusion in the study.
Exclusion Criteria:
* Pregnant or lactating women.
* They cannot offer cooperation.
* Participation in a study or clinical trial during the 3 months prior to inclusion.
* Patients with fibromes.
* Patients with PCOS.
* Patients with some genetic alteration (altered karitype, cystic fibrosis, multiple sclerosis, rheumatoid arthritis...)
* Patients chronic infectious disease.
* Patients in maintenance treatment with immunosuppressants.
* Patients who have received systemic corti…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.