This study will compare medically-supervised withdrawal (MSW, 'detoxification') to opioid agonist treatment (OAT, 'maintenance') with buprenorphine for pregnant women with opioid use disorder in terms of maternal, fetal, and neonatal outcomes. Outcomes will be assessed during pregnancy, at birth and for 12 months postpartum. This study has the potential to impact health service policy and practices in terms of the treatment options of pregnant women with opioid use disorder.
Age range
18 Years – 41 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Proportion of mothers who discontinued 1st treatment choice prior to delivery
Timeframe: Antepartum period
Proportion of mothers engaged in treatment at delivery
Timeframe: Antepartum period
Proportion of mothers with illicit substance use at delivery
Timeframe: At delivery
Proportion of mother-child dyads with delivery complications
Timeframe: At delivery
Proportion of neonates receiving medication treatment for neonatal abstinence syndrome (NAS)
Timeframe: At hospital discharge, an average of 10 days after delivery
Total average amount of medication given to treat NAS
Timeframe: At hospital discharge, an average of 10 days after delivery
Total average length of neonatal hospital stay
Timeframe: At hospital discharge, an average of 10 days after delivery