Neoadjuvant Immunotherapy in Early Stage Non-small-cell Lung Cancer Presenting as Synchronous Ground-glass Nodules

Inclusion Criteria: * not less than two GGNs on chest CT * at least one lesion is diagnosed as NSCLC from biopsy pathology * no contraindication for surgery * ECOG score of 0 or 1 * no detectable evidence of distant metastasis Exclusion Criteria: * medical history of malignancy * pregnant or breeding period * severe organ failure (heart, liver, kidney, and lung) * high risk of cerebral-cardiovascular evens * infection out of control * received or receiving chemo- and radiotherapy * history of severe reaction due to allergy or hypersensitivity * severe mental disorder * currently been enrolled in other trials * autoimmune or chronic inflammatory disease