Dose-Ranging Study of ST-920, an AAV2/6 Human Alpha Galactosidase A Gene Therapy in Subjects With Fabry Disease (STAAR)

Inclusion Criteria: * ≥ 18 years of age * Documented diagnosis of Fabry disease * One or more of the following symptoms: i) cornea verticillata, ii) acroparesthesia, iii) anhidrosis, iv) angiokeratoma * Subject must be fully vaccinated (as per the Centers for Disease Control and Prevention (CDC) definition in the US and as per local guidelines in other countries) for Coronavirus Disease (COVID-19) at least one month prior to dosing Additional Inclusion Criteria: Renal Cohort: * Screening estimated glomerular filtration rate (eGFR) value between 40-90 mL/min/1.73 m² * Linear negative eGFR slope (estimated from at least 3 serum creatinine values within 18 months, including the value obtained during screening visit) of ≥ 2 mL/min/1.73m²/year Cardiac Cohort: • Left ventricular hypertrophy (LVH) in 2D echocardiography or cardiac magnetic resonance imaging (CMR) defined as an end diastolic septum and posterior wall thickness ≥12 mm with no other explanation for LVH, OR presentation with cardiac changes indicative of disease progression such as decreased global longitudinal strain on 2D strain echocardiography or low native T1 mapping on CMR Exclusion Criteria: * Neutralizing antibodies to AAV6 * eGFR \< 40 ml/min/1.73m2 * New York Heart Association Class III or higher * Active infection with hepatitis A, B or C, human immunodeficiency virus (HIV) or tuberculosis (TB) * History of liver disease such as clinically significant steatosis, fibrosis, non-alcoholic steatohepatitis…