This is a randomized crossover-designed study to explore the immunologic effects of Prebiotics, as opposed to direct supplementation with beneficial bacteria (Probiotics) in the immune system of patients with MS and Clinically Isolated Syndrome (CIS). Eligible patients will take 6 weeks of two different supplements - Prebiotics and Probiotics. Participants will be randomly assigned to take either of two agents for 6 weeks as their first supplement. Then, participants enter a 6-week washout period. After the washout period, participants will take the second supplement for 6 weeks. After taking the second supplement, participants will have a 6-week washout period.
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Change in Peripheral Blood Mononuclear Cells (pBMCs)
Timeframe: Up to 24 weeks
Change in Serum Neurofilament Light Concentration
Timeframe: Up to 24 weeks
Change in relative abundance of gut microbiome
Timeframe: Up to 24 weeks