The PrEP (Pre-exposure Prophylaxis) SMART Study

Inclusion Criteria: * Female at birth * Age 18-25 years * Per participant report, sexually active, defined as having vaginal or anal intercourse at least once in the month prior to screening * Literate in one or more of the study languages * Willing and able to provide informed consent * Able and willing to provide adequate locator information * Regular access to a mobile phone with SMS and WhatsApp capacity * Agrees not to participate in other research studies involving drugs or medical devices for the duration of study participation Exclusion Criteria: * Planning to relocate in the next 12 months * Has a job or other obligations that would require long absences from the area (\> 4 weeks at a time) for 12 months * A reactive or positive HIV test at Enrollment * Any reported PrEP use within the last 6 months * Concomitant participation in a clinical trial using investigational agents, including placebo-controlled clinical trials using such agents * Prior participation in the active arm, or current participation in any arm, of an HIV vaccine trial * Positive pregnancy test