Paracetamol Versus Ibuprofen in Premature Infants With Hemodynamically Significant Patent Ductus Arteriosus

Inclusion Criteria: * Written Informed consent of parents/guardians * Gestacional Age ≤30 weeks * Postnatal age ≤ 2 weeks * Need for ventilatory support * Born in participating hospital/arrival to them within the period of application of the treatment * 1 st episode of hemodynamically significant Patent Ductus Arteriosus Exclusion Criteria: * Major congenital malformations or chromosomopathies * Refusal to participate and / or sign the informed consent. * Impossibility or erroneous randomization * Participation in another clinical trial with drugs * Diuresis less than 1 ml / kg / h for 8 h prior to treatment * Greater than 1.8 mg / dl Creatinine * Platelets below 50,000 / uL * Active bleeding (tracheal, gastrointestinal and renal) * Intraventricular hemorrhage recently (48h) (grades 3-4) * Severe hyperbilirubinemia * Liver failure or severe coagulopathy * Active necrotizing enterocolitis or intestinal perforation * Septic shock * Imminent death