Stopped: Did not secure funding.
Hyperpolarized (HP) gas magnetic resonance imaging (MRI) of the lungs offers additional information that cannot be obtained with CT scan, the current gold standard for imaging this disorder. As a nonionizing technique, MRI is an ideal modality for pulmonary imaging; in particular in the infant and pediatric population. Nevertheless, due to the low proton density of the lung parenchyma (only \~20% that of solid tissues), numerous air-tissue interfaces that lead to rapid signal decay, and cardiac and respiratory sources of motion that further degrade image quality , MRI has played a limited role in the evaluation of lung pathologies. In this setting, HP gas (using 129Xe) MRI may play a role in helping determine the regional distribution of alveolar sizes, partial pressure of oxygen, alveolar wall thickness, and gas transport efficiency of the microvasculature within the lungs of infants with a diagnosis of bronchopulmonary dysplasia (BPD).
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Analyze 129Xe MRI ventilation maps for regions of abnormal ventilation.
Timeframe: 2 years
Analyze 129Xe MRI ADC maps and check for regions of deviations from literature reported normal values.
Timeframe: 2 years
Analyze oxygen partial pressure (PAO2) maps extracted from 129Xe MRI
Timeframe: 2 years
Analyze gas exchange and transport coefficient maps and global values as extracted from 129Xe MRI.
Timeframe: 2 years