The purpose of this study is to evaluate the effect of a parenteral emulsion containing n-3 long-chain polyunsaturated fatty acids (LC-PUFA) in fish oil on clinical outcomes, markers of inflammation and oxidative stress, and pain in neonates with persistent pulmonary hypertension of the newborn (PPHN) compared with those who receive an emulsion containing soy oil and medium-chain triglycerides (MCT) without n-3 LC-PUFA.
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Change on systolic pressure of pulmonary artery
Timeframe: Before surgery (baseline), 24 hour, 48 hour, 72 hour, day 7, day 14 and day 21 post-surgery.
Preductal partial pressure of carbon (PaCO2)
Timeframe: Before surgery (baseline), 24 hour, 48 hour, 72 hour and day 7 post-surgery.
Change in Preductal and postductal oxygen saturation (SatO2)
Timeframe: Before surgery (baseline), 24 hour, 48 hour, 72 hour, day 7, day 14 and day 21 post-surgery.
Inspired fraction of oxygen (FiO2)
Timeframe: Before surgery (baseline), 24 hour, 48 hour, 72 hour, day 7, day 14 and day 21 post-surgery.
Growth velocity and Nutritional status
Timeframe: Before surgery (baseline), day 7, day 14 and day 21 post-surgery.
Pain manifestation
Timeframe: Before surgery (baseline), 24 hour, 48 hour, 72 hour, day 7, day 14 and day 21 post-surgery.