CompletedNot Applicable

Carbohydrate Intake and Gut Hormone Release During Exercise

United Kingdom12 participantsStarted 2019-02-21

Plain-language summary

It is well known that following a single session of moderate-to-high intensity exercise individuals experience a temporary suppression of hunger and a delay in the commencement of eating. This effect is believed to be due to changes in blood concentrations of specific hormones released from the gut that influence appetite. Individuals undertaking physical activity often consume foods immediately before exercise in order to improve their performance. However, it is currently unknown whether this eating practice influences the gut hormone response to exercise as well as how hungry an individual feels post-exercise. Therefore, the aim of this study is to investigate the effect of consuming a sugary (carbohydrate) drink immediately before starting an exercise session on the concentration of these gut hormones as well as the amount of food eaten in the hours following exercise completion.

Who can participate

Age range18 Years – 40 Years

SexMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male * Age between 18-40 years (inclusive) * Body mass index (BMI) of 18-30 kg/m2 * Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements Exclusion Criteria: * Abnormal ECG * Screening blood results outside of normal reference values * Current smokers * Current or history of substance abuse and/or excess alcohol intake * Diabetes * Cardiovascular disease * Cancer * Gastrointestinal disease e.g. inflammatory bowel disease or irritable bowel syndrome * Kidney disease * Liver disease * Pancreatitis * Started new medication within the last 3 months likely to interfere with energy metabolism, appetite regulation and hormonal balance, including: anti-inflammatory drugs or steroids, antibiotics, androgens, phenytoin, erythromycin or thyroid hormones. * Participation in a research study in the 12 week period prior to entering this study. * Any blood donation within the 12 week period prior to entering this study

What they're measuring

Changes in GLP-1 concentration

Timeframe: During the study visit, 165 minutes

Changes in PYY concentration

Timeframe: During the study visit, 165 minutes

Changes in acylated ghrelin concentration

Timeframe: During the study visit, 165 minutes

Trial details

NCT IDNCT04019418

SponsorImperial College London

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-02-12

View on ClinicalTrials.gov More Obesity trials

Plain-language summary

Who can participate

Age range18 Years – 40 Years

SexMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.