Task Shifting to Treat Depression and HIV Medication Nonadherence in Low Resource Settings (NCT04018391) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Task Shifting to Treat Depression and HIV Medication Nonadherence in Low Resource Settings
Zimbabwe280 participantsStarted 2019-07-12
Plain-language summary
A hybrid effectiveness-efficacy trial to evaluate a stepped care task shifted intervention to treat depression and HIV medication nonadherence in low resource settings in rural Zimbabwe.
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Initiated on ART for at least 6 months
* Clinically significant depression symptoms scoring \>/= 10 on the Patient Health Questionnaire-9
* Viral non-suppression in past two months per local clinic standard (VL \> 1000 copies/mL)
* Able to provide informed consent
* If prescribed antidepressants, on stable regimen for at least 2 months
Exclusion Criteria:
* Unable to provide informed consent
* Active major mental illness (e.g. untreated psychosis or mania, actively suicidal), major untreated or undertreated mental illness or advanced physical disease or severe cognitive impairment assessed using the psychosis module of the MINI, the PHQ-9, and the International HIV dementia Scale which would interfere with engagement in PST-AD
* Has ever received PST or CBT for depression
* Less than 18 years of age
What they're measuring
1
Viral Suppression
Timeframe: 12 - month post randomization study visit